By Cross-Reactive T Cells Share pMHC Structural Features Recognized Heterologous Immunity to Unrelated Viruses Disparate Epitopes Mediating Protective
نویسندگان
چکیده
منابع مشابه
Disparate epitopes mediating protective heterologous immunity to unrelated viruses share peptide-MHC structural features recognized by cross-reactive T cells.
Closely related peptide epitopes can be recognized by the same T cells and contribute to the immune response against pathogens encoding those epitopes, but sometimes cross-reactive epitopes share little homology. The degree of structural homology required for such disparate ligands to be recognized by cross-reactive TCRs remains unclear. In this study, we examined the mechanistic basis for cros...
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تاریخ انتشار 2013